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Jun.29,2017 The page was updated.
Apr.1,2017 We moved to a new laboratory.
Aug.9,2015 We were published in the column of JOBKULMAGAZINE (Japanese).
Sep.16,2014 We exhibited our new 8-oxo-dG assay kit (prototype) to "MEDICAL FAIR ASIA 2014" in Singapore.
  8-hydroxy-2'-deoxyguanosine (8-oxo-dG)



  Four bases (adenine, thymine, guanine, and cytosine) encode all the genetic information on a double strand of DNA. The common base pairing is A:T and G:C. However, even under stable conditions, a typical oxidized deoxyguanosine (dG), which is known as 8-oxo-dG, can be directly generated on the DNA sequence or near the DNA by hydroxyl radicals, with constant probability. As a result, if dG is replaced by 8-oxo-dG, a G:C ⇒ T:A transversion occurs with high probability. Constant changes in the base code may promote the diversification and evolution of the organism.

  Besides the oxidative metabolic process, toxic chemicals & metals, and radiation including ultraviolet and radioactive rays are considered to be inducers of hydroxyl radicals. A change in genetic code contributes to, but is sometimes the definitive factor in, diseases such as cancer, arteriosclerosis in multiple organs, Alzheimerfs disease, apoptosis, and pathophysiological changes of aging. The GO index indicates the risk of individual and epidemiological survival.



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